apalutamide will lower the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine which have been CYP3A4 substrates may lead to reduce publicity to these drugs.modafinil will increase the amount or outcome of rabepra

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